Stags' boss Nigel Clough makes two changes to the side that drew 0-0 away at Barrow a week ago.
Deadline day signing, Jamie Murphy, makes his debut against Colchester this evening.
Lucas Akins replaces Jordan Bowery in the starting XI and Ollie Clarke drops to the bench in place of Murphy.
Matty Longstaff is included in the matchday 18, the midfielder also joined the club on deadline day, on loan from Newcastle.
Oli Hawkins captains the side and looks set to partner John-Joe O'Toole at centre-back.
Starting: Bishop, Hewitt, O'Toole, Hawkins, McLaughlin, Stirk, Maris, Quinn, Murphy, Oates, Akins.
Subs: Stech, Rawson, Clarke, Wallace, Longstaff, Bowery, Johnson.